Effect of a novel tyrosine kinase inhibitor nintedanib on bFGF and VEGF concentrations in a rabbit retinal vein occlusion model

نویسندگان

چکیده

AIM: To evaluate whether a novel tyrosine kinase inhibitor nintedanib could inhibit basic fibroblast growth factor (bFGF) and vascular endothelial (VEGF) simultaneously for retinal disease in vivo. METHODS: After laser induced rabbit vein occlusion (RVO) model was made, 0.5 mg of injected intravitreally the left eye on third day while right as control. Intracameral samples were taken before treatment days 1, 3, 7, 14, 21, 28 after treatment. Enzyme-linked immunosorbent assay (ELISA) used to test bFGF VEGF-A concentrations aqueous humor. RESULTS: Both rose significantly both eyes. In control concentration peaked 14th dropped rapidly soon day. nintadanib injection study eye, showed significant reduction 4th (7th treatment) when compared kept low level following several weeks. CONCLUSION: Intravitreal can expression VEGF process RVO certain extent, which is expected become new method diseases or fibrotic diseases.

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ژورنال

عنوان ژورنال: International Journal of Ophthalmology

سال: 2023

ISSN: ['2227-4898', '2222-3959']

DOI: https://doi.org/10.18240/ijo.2023.09.11